IVIg requires the expression of the activating Fc receptor FcγRIIIA on dendritic cells to ameliorate murine ITP [10] and it has been demonstrated that the in vitro activation of macrophages by immune complexes results in association of TLR4 with FcγRIIIA [28]. Here, FCGR3A is linked to autoimmune thrombocytopenic purpura.