As CNS lymphoma microenvironment is rich in IL-4 [12,13] and as IL-4 is known to induce M2 polarization of macrophages [14], IL-4 treatment followed by DMSO or POM treatment was tested on U937 (Figure 7), primary microglial cells (Figure S2), and primary peritoneal macrophages (Figure S3). The gene discussed is IL4; the disease is primary central nervous system lymphoma.