In the spleens, similar to the JaOArS982 infection, the levels of IFN-γ, IL-2 and IL-4 in IL-10 KO and TNF-α KO mice were significantly increased compared with those of WT mice at 7 days pi following JaTH160 infection, whereas the level of IL-5 was decreased in TNF-α KO (Figure S5B). The gene discussed is IL4; the disease is infection.