In this study, it was revealed that: i) serum levels of BAFF in patients with PDAC (in particular, in those with metastasis) were elevated compared to healthy subjects; ii) tumor-infiltrating B lymphocytes expressed BAFF and PDAC tissues expressed BAFF-R; and iii) increased BAFF-induced gene alterations were associated with EMT in a PDAC cell line, and with enhanced tumor cell motility and invasion. The gene discussed is TNFSF13B; the disease is neoplasm.