Since T cells play a critical role in initiating and propagating asthma and γc−/− mice lack T-cells, we used an asthma model wherein we provided in vivo-primed OVA-specific OT-II T cells to γc–sufficient RAG2−/−, γc−/−, or γcxRAG2−/− mice using a previously established transfer model [13]. The gene discussed is GC; the disease is asthma.