[56] The rs3091244 SNP did show association in our study during McNemar chi square analysis; but this was not supported after multivariate adjustment. The rs1800947 SNP failed to show any significant association in this study. Another SNP (rs2808630) in linkage disequilibrium with rs876538 (r2 = 0.63, d′ = 1) affects CRP expression.[57] However, rs876538 was associated, in an Australian population, with improved treatment response in neovascular age-related macular degeneration. [58]. Here, CRP is linked to wet macular degeneration.