Since all the pathways of these subtypes of cardiomyopathies involve integrins, dystroglycan complex and sarcomere (Figure 2, Figure S1, and S2), which are important in cardiac myocyte and cardiac muscle contraction [75], [76], it suggested that there was a crosstalk of these three subtypes of cardiomyopathies, especially between DCM and HCM. The gene discussed is DAG1; the disease is familial dilated cardiomyopathy.