ACTA1 and hepatocellular carcinoma: As shown in Table 1 (detailed in Tables S4 and S5 in File S1), in HCC, patients with a low α-SMA density were prone to have presence of intrahepatic metastasis and microvascular invasion, and low tumor differentiation; high MVD was associated with large tumor size, high serum α-fetoprotein concentration, presence of intrahepatic metastasis and microvascular invasion, and high TNM stage.