RHD and anemia: [1], [2] Affected pregnancies require close surveillance in order to detect fetal anemia in a timely manner, and the neonates often require treatment for hyperbilirubinemia and anemia. RhD immunisation is the commonest indication for intrauterine blood transfusion and neonatal exchange transfusion. [3], [4] Once a woman is RhD immunised, all her subsequent pregnancies with an RhD positive fetus will be affected.