However, in colorectal cancer specifically, CD166 expression was associated with more advanced T category (RR = 0.93, 95% CI: 0.88–0.98) and N-positive status (RR = 1.17, 95%CI 1.05–1.30), and it did not show any relationship with other kinds of digestive tumors. The gene discussed is ALCAM; the disease is digestive system neoplasm.