It is worth noting that factors that attenuate Fas signaling have been suggested per se as a potential avenue for therapeutic intervention for AD [43] since increased levels of Fas protein have been reported in the brain and cerebrospinal fluid of AD patients [44], [45] and the Fas gene is located in the 10q24.1 region showing linkage to late onset AD [46], [47] with polymorphisms in Fas having shown association with AD progression [48], [49]. Here, FAS is linked to Alzheimer disease.