In turn, the GSK3β pY216 can account for the activation of the mitochondrial-death pathway (intrinsic pathway) [35], which results in increased cytochrome c release from the mitochondria [56], [57] and activation of caspase-9 and −3 in the 6-OHDA PD rat model [26], [28]. This evidence concerns the gene GSK3B and Parkinson disease.