The reasons for this approach are that preventative therapy with low dose aspirin is effective for reduction of preeclampsia and SGA when initiated at 16 and up to 20 weeks’ gestation [43], [44], more women have booked for antenatal care and biomarker discrimination in particular with PlGF has been shown to improve between samples obtained in the first trimester and 15–16 weeks’ [45]. This evidence concerns the gene PGF and preeclampsia.