When analyzed by western blotting assay, no intact (270 kDa) N-CoR was detected in various AML-M5 derived cell lines; though an intact N-CoR of 270 kDa was evidently presented in all three non-AML-M5 derived cell lines U937, K562 and HL-60 used as controls (Fig. 1A). The gene discussed is NCOR1; the disease is acute myeloid leukemia.