Further data in support of a coinhibitory role of B7-H3 in the regulation of immune response came from in vivo experiments showing that Th1-mediated hypersensitivity, and that the onset of experimental autoimmune encephalomyelitis and allergic conjunctivitis were augmented in B7-H3 knock-out mice [28], [29]. The gene discussed is CD276; the disease is experimental autoimmune encephalomyelitis.