For example, several independent studies have shown that markedly increased expression of B7-H3 protein in human malignant tumor cells is associated with increased disease severity in breast cancer [19], colorectal carcinoma [30], hepatocellular carcinoma [31], prostate cancer [32], non-small-cell lung cancer [33] and neuroblastoma [34]. This evidence concerns the gene CD276 and Familial prostate cancer.