However, sarcoidosis patients responding successfully to treatment showed a significant increase in transcriptional activity by MDTH of inflammatory transcripts, including the anti-inflammatory genes, IL1R2, IL18RAP, DUSP1, FOS, IκBα and MAPK1, which invariably accompany the activation of inflammatory pathways [33], [34], [35]. Here, IL1R2 is linked to sarcoidosis.