HVCN1 and colorectal adenoma: To investigate Hv1 for use as a potential biomarker and therapeutic target for colorectal cancer, Hv1 expression in 139 colorectal cancer tissues and paired normal tissues, 10 normal colorectal, 20 colorectal adenoma and 18 hyperplastic polyp tissues, was detected using immunohistochemistry with an anti-Hv1 polyclonal antibody that was generated in house.