When decitabine was used in combination with chidamide, significant increase in PRAME expression was observed in all 4 AML cell lines as compared with chidamide treatment alone (Figure 5A), though neither chidamide alone nor combined treatment with decitabine significantly increase PRAME expression in K562 cells or in bone marrow cells from patient #5 in Table 1 (Figure S5). Here, PRAME is linked to acute myeloid leukemia.