STAT3 and familial pancreatic carcinoma: In EGF-STAT1 and EGF-STAT3, both gene pairs are involved in pancreatic cancer, EGF pathway, and signal transduction pathway; both STAT1 and STAT3 are activated by the Jak kinase in response to EGF [53]–[55], where JAK2/STAT3 signaling is required for EGF-driven ovarian cancer [55].