In APEX1-HIF1A and HIF1A-TEP1 having the CNA-CNA relationship, APEX1 and HIF1A directly interact with each other in vitro[44]; and, in GBM, copy number loss at 14q11.1-q13.1, 14q23.2-q23.3, and 14q32.33, where these genes are located, has been reported by Donovan et al.[45]. This evidence concerns the gene APEX1 and glioblastoma.