GBM Module 2 contains many previously known GBM-related KEGG pathways including Glioma, P53 signaling, MAPK signaling, ERBB signaling, mTOR signaling, and VEGF signaling, and GBM-related BioCarta pathways, including ATM, G2, G1, RB, P53, PTEN, and MET pathways [48]. This evidence concerns the gene RB1 and central nervous system cancer.