In BRCA2-ING1, both genes play critical roles in cell cycle control [35], [36]; ING1 is a tumor suppressor gene and interacts with TP53, and its under-expression and genetic rearrangement have been observed in several cancers, including GBM [37]; and BRCA2, a tumor suppressor gene, has recently been targeted for sensitizing glioma cells for killing by anti-cancer drugs [38]. This evidence concerns the gene TP53 and central nervous system cancer.