The gene sets overlapping with the transcripts altered in melanoma cell lines 24 hours after cisplatin treatment were highly correlated with DNA repair and DNA damage response genes that included BRCA1, BRCA2, ATM and CHEK2. As well as these DDR genes there was a highly significant (p<1×10−20) overlap of genes with altered expression after UV irradiation in ERCC3 (XPB) mutant cells. This evidence concerns the gene ERCC3 and melanoma.