mGluR5 dependent synaptic plasticity has been found in a diverse range of synaptic connections [9], [10], [11], [12] and mGluR5 signaling has been implicated in the pathology of several significant neurological disorders, including Fragile X syndrome (FXS) [13], [14], [15], [16], [17], [18], attention-deficit/hyperactivity disorder (ADHD) [19], [20], autism [21], [22], schizophrenia [2], [19], [23], and epilepsy [24]. The gene discussed is GRM5; the disease is fragile X syndrome.