CD4 and hepatocellular carcinoma: Recently, it has been reported that biologic behaviors of HCC are associated with a unique immune response signature [3], increased CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) may promote hepatitis B virus-related HCC progression [4], and intratumoral balance of regulatory and cytotoxic T cells is a promising independent predictor for recurrence and survival [5], [6].