CD8A and neoplasm: Another reason was that iNKT cells had a dual immune regulatory function, as Carian et al [41] had shown, iNKT cells producing Th2 cytokines might inhibit anti-tumor immunity through inhibiting expansion of tumor antigen-specific CD8 T cells, but iNKT cells could promote successful tumor immunosurveillance through secreting IFN-γ or under the Th1 microenvironment, which was consistent with the present study.