For example, we identified SNPs in the far upstream element (FUSE) binding protein 1 (FUBP1), peroxisome proliferator-activated receptor alpha (PPARA) and transcription factor Dp-1 (TFDP1) that might affect exon splicing for these genes, and these SNPs were found only in the CRC tissues (Table 3). The gene discussed is TFDP1; the disease is colorectal carcinoma.