IGHE and hereditary angioedema type 1: HK proteolysis was investigated on plasma samples from representative patients with HAE I, HAE-nC1INH not carrying F12 mutation, during OC (HAE-nC1INH+OC) and after withdrawal of the pill (HAE-nC1INH – OC) and IgE-AE, as representative examples of the cohort above described.