Similarly to the above detailed explanations, in the hyperdiploid sample group, the SNPs in the TYMS gene were related to HD-ALL with probabilities of 0.72–0.77 mediated through the effect of rs1004474; and SNPs in MTRR (rs2966952, rs1801394, rs326120, rs162036 and rs10380) were associated (0.79–0.82) via rs1532268 and rs3776455 (Table S8). This evidence concerns the gene TYMS and acute lymphoblastic leukemia.