Altogether 9 SNPs (rs2235013, rs12517451, rs1544105, rs1076991, rs12759827, rs9909104, rs2853533, rs3776455, rs1532268) in 8 genes (ABCB1, DHFR, FPGS, MTHFD1, MTR, SHMT1, TYMS, MTRR) showed nominally significant association with the risk to ALL. This evidence concerns the gene SHMT1 and acute lymphoblastic leukemia.