Secondary hyperparathyroidism (SHPT) is one of the most important and well-recognized of these disorders and data from observational studies have shown that CKD patients presenting high levels of serum parathormone (PTH) have an increased risk for mortality, as well as a higher morbidity [1], [2], [3].The Dialysis Outcomes and Practice Patterns Study (DOPPS) is the most important ongoing observational study and its results indicated that serum PTH higher than 600 pg/ml was associated with a 21% increase in all-cause mortality risk [3]. The gene discussed is PTH; the disease is chronic kidney disease.