Moreover, whereas adenocarcinomas were detected in 46.4% of the CDON+/+APC+/1638N control mice, consistent with previous reports [33], the frequency of CDON−/−APC+/1638N mice with adenocarcinomas was markedly increased to 77.6% (Figure 4F; p<0.05). The gene discussed is APC; the disease is adenocarcinoma.