Thus together with the loss of expression of CDON in a fraction of human cancers and with the fact that high-throughput sequencing consortia have reported the presence of a large number of sprayed missense mutations in the coding sequence of CDON in human cancers (see http://cancer.sanger.ac.uk/cosmic/gene/overview?ln=CDONN), these data argue that CDON is a bona fide tumor suppressor probably thanks to its dependence receptor function. The gene discussed is CDON; the disease is neoplasm.