GFER and neoplasm: The core kinase cascade of the Hpo pathway consists of four tumor suppressor proteins, including two kinases, the serine/threonine Ste20-like kinase Hpo or its mammalian homologues MST1/2 [8]–[12], and the nuclear Dbf-2-related (NDR) family kinase Warts (Wts) or its mammalian homologues LATS1/2 [13],[14], and the scaffold proteins of the kinases, Salvador (Sav) [15],[16] and Mob as tumor suppressors (Mats) [17].