In addition to inducing a “sliceopathy,” the repeat expansions may also induce disease through altered function of DMPK and ZNF9, dysregulated expression of neighboring genes, and repeat associated non-ATG translation.33–36 Recent studies have also begun to elucidate the role of repeat expansions in the central nervous system (CNS) manifestations of myotonic dystrophy, including cognitive dysfunction and sleep disorders.37,38. This evidence concerns the gene DMPK and myotonic dystrophy.