The most frequent LRRK2 mutation, p.G2019S, while barely present in Asia (<0.1%), is responsible for up to 10% of apparently sporadic PD and up to 42% of familial PD [5, 8]; although this mutation has a worldwide distribution, it is present with a higher frequency in Portuguese (16%), Ashkenazi Jewish (28%), and North African Arab (42%) populations [9–11]. The gene discussed is LRRK2; the disease is Parkinson disease.