Mutations or deletions in different genes have been identified as involved in lissencephaly cases: the LIS gene is responsible for the autosomal form of classical lissencephaly[13] and the doublecortin gene (DCX or X-LIS) is X-linked[14] whereas homozygous RELN gene has been identified in cases of LCH[10]. This evidence concerns the gene RELN and lissencephaly spectrum disorders.