Treatment with SC-43 at 10 mg/kg/day did not significantly inhibit the tumor growth of STAT3-overexpressed MDA-MB-468 tumors and failed to suppress p-STAT3 expression in these tumors (Figure 5C, right), indicating the pivotal role of downregulation of p-STAT3 in mediating the drug effects of SC-43. Here, STAT3 is linked to neoplasm.