Moreover, agents such as betulinic acid [15], boswellic acid [16], gambogic acid [17], dihydroxypentamethoxyflavone [18], butein [19], icariside II (a flavonoid icariin derivative) [20] and 5-hydroxy-2-methyl-1,4-naphthoquinone (a vitamin K3 analogue) [21] that can enhance the SHP-1 pathway (either by induction of SHP-1 expression or by increase of SHP-1 activity) have all shown anti-cancer potential. Here, NR0B2 is linked to cancer.