TNFRSF8 and neoplasm: Based on morphology alone, it is almost impossible to distinguish CHL with abundant numbers of neoplastic cells from other primary cutaneous lymphoproliferative disorders, such as CD30+ lymphoproliferative disorder (lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large-cell lymphoma (ALCL)), or even tumor stage mycosis fungoides when the epidermotropism is minimal.