Adaptive tolerance to hypoxia stress in Spalax, both in vivo and in vitro, may grant the unique resistance to cancer through strong antioxidant mechanisms, among others (for example, as mentioned here, the unique activity of its p53 [8] and heparanse [9]), that quench ROS before they spread and damage DNA and other macromolecules, thus providing cellular homeostasis and cancer protection. The gene discussed is TP53; the disease is cancer.