Gonadotropin-dependent and gonadotropin-independent precocious puberty can be distinguished by differences in the responses to GnRH-stimulation testing, as GnRH-stimulated luteinising hormone (LH) and follicle stimulating hormone (FSH) concentrations are suppressed in pseudoprecocious puberty, but increased in central precocious puberty [8]. Here, PLOD1 is linked to central precocious puberty.