The resistance of mesothelial cells to erionite-induced toxicity and erionite’s ability to cause activation of the NLRP3 inflammasome as well as production of IL-1β and other cytokines at non-toxic concentrations may be of mechanistic significance to promulgation of erionite-transformed cells and its increased potency in MM carcinogenesis. The gene discussed is NLRP3; the disease is Miyoshi myopathy.