In addition to abrogating the inflammatory mechanisms of mature IL-1β that may also orchestrate the expression, production, and effects of IL-6, IL-8 and VEGF, this approach may be valuable in preventing the ramifications of robust production and release of IL-1 from necrotic and neighboring mesothelial cells after infection [40] or exposure to asbestos fibers. The gene discussed is CXCL8; the disease is infection.