CHI3L1 and respiratory system disorder: On the other hand proteomics research, being able to recognize specific protein clusters (MMP1 and 7, SPP1, YKL-40, etc.)[17], could complement genetic investigation and contribute to the building of a biological “profile” of the pathology: many of the current obstacles may be overcome through increased access to data from the Lung Tissue Research Consortium [66], founded by the National Health Institute with the aim of collecting biological and clinical material concerning respiratory diseases, particularly COPD and ILD.