MMP1 and chronic obstructive pulmonary disease: Rosas et al. [37] showed that a combined increase in serum MMP1 and MMP7 was discriminating between IPF and other ILDs or COPD, which suggested for these molecules a diagnostic role and, for MMP7 only, also a prognostic one, so that Richards et al. [53] have developed a mortality-predictive multidimensional index involving integration of plasmatic MMP7, FVC and DLCO.