NFE2L2 and neoplasm: As is shown in Figure 5A and Figure 5B, procreating GSCs treated with the Nrf2 shRNA lentivirus resulted in a tumor volume of 210 ± 57 mm3, compared with a much larger volume of 1850 ± 260 mm3 in tumors treated with the Scrambled shRNA, and control tumors (1900 ± 300 mm3; Figure 5A, B, and C).