In the second dimension, some genes including EGFR,MAPK9, MMP14 and CDKN2A from the Epithelial cell signaling in helicobacter pylori infection, p53 signaling, GnRH signaling and metabolic pathways are over-expressed in melanoma cells and involve with cellular growth, migration and metastasis [44-46]. Here, MMP14 is linked to melanoma.