Tn-C is highly expressed during human lung development but can also be detected in many lung diseases such as asthma, IPF, asbestosis, respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD) and granulomatous lung diseases associating with the increase of α-SMA positive cells, obvious myofibroblasts [12,17-23]. Here, ACTA1 is linked to newborn respiratory distress syndrome.