HLA-DRB1 and leprosy: The HLA-DR2 molecule [12, 13, 15, 21–24, 29, 32], later identified as DRB1*15 and DRB1*16 variants, is primarily associated with leprosy (LD or different clinical forms) in Indian, Japanese, Brazilian, and Chinese patients [25–27, 30, 33, 35, 36, 38, 39, 42].