Whereas the ZODIAC trial, which compared vandetanib plus docetaxel (N = 694; of those 412 had adenocarcinoma, 184 had squamous, and 98 had other histology) versus placebo plus docetaxel (697 patients; of those 417 had adenocarcinoma, 160 had squamous, and 120 had other histologies) [71], the ZEPHYR trial (924 patients; of those 726 had adenocarcinoma, 102 had squamous, and 96 had other histologies) evaluated vandetanib in patients with advanced NSCLC, and prior EGFR TKI therapy demonstrated significantly improved PFS for the combination but did not significantly improve OS [72]. Here, EGFR is linked to adenocarcinoma.