ERBB2 and non-small cell lung carcinoma: For example, the expression of HER family members (HER-2), not EGFR expression, is correlated with the efficacy of gefitinib, and it has been found that adenocarcinomas of the lung are more likely to have increased immunohistochemical staining for HER-2 than squamous cell or other NSCLC histologies [96].