TNFSF4 and lobular neoplasia: Indeed, from a genome-wide gene-expression analysis from kidney biopsy which included larger samples, it was observed that TNFSF4 mRNA expressions were downregulated both in glomeruli (5.61 ± 0.24 versus 5.76 ± 0.18; P = 0.044; 32 LN patients versus 14 controls) and in tubulointerstitium (4.64 ± 0.12 versus 4.72 ± 0.14; P = 0.052; 32 LN patients versus 15 controls) from LN patients compared with those from controls [9].