Moreover, we correlated them with markers of myeloma activity, such as serum levels of IL-6, IL-10, IL-15, beta-2 microglobulin (B2M), and C-reactive protein (CRP), as well as with plasma cells' infiltration and Ki-67-PI in the bone marrow, both in diagnosis and after effective therapy. This evidence concerns the gene IL6 and plasma cell myeloma.