On the basis of the study of Darreh-Shori et al. [85] who have explored the roles of the two AChE variants in the Alzheimer disease, it is possible to hypothesize the involvement of the AChE different spicing isoforms in the organophosphate association with Alzheimer's disease in exposed individuals. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.