TLR4 and chronic obstructive pulmonary disease: Budulac et al. (2011) have shown the association of TLR4 polymorphisms with infection status and disease outcome in Chronic Obstructive Pulmonary Disease while Miedema et al. (2011) showed that TLR4 polymorphisms were associated with risk of developing neutropenia in leukemic children [37, 38].