Previous studies showed that E5 does not promote any changes in ERK activity in cultured fibroblasts [22, 55] as well as in BPV-induced tumours in vivo: it is therefore possible that pPDGFβR activates GRB2, Sos1, and Ras which may deviate on phosphatidylinositol-3-kinase/AKT pathway (PI3 K/AKT). The gene discussed is GRB2; the disease is neoplasm.