We note that the upregulated markers of alternative activation are likely to be relevant to the inflammatory response, because eotaxin-2/CCL24 cooperates with IL-13 in the recruitment of eosinophils [44], Ym1 may also have a role in eosinophil recruitment [45], while FIZZ1 may contribute to the development of airway hyperresponsiveness [46]. Here, RETNLB is linked to airway hyperresponsiveness.