GRM5 and myeloid sarcoma: In the present study, we investigated whether drugs such as LY 367385 (a mGluR1 selective antagonist) MPEP (a mGluR5 antagonist) and amantadine and memantine (antagonists of NMDA glutamate receptors, which inhibit excitatory glutamatergic neurotransmission through different mechanisms), have neuroprotective effects in the established rat model of MS.