Additionally, the RSK2 protein levels in various cancer cell lines such as H460, MCF-7, HCT-116, HCT-29, PC-2, Du-145, SoaS-2, A431, SK-MEL-5, SK-MEL-28, and RPMI 1640 are higher than compared with non-malignant human and mouse cells including HaCaT, JB6 Cl41, and NIH3T3 cells (17). This evidence concerns the gene RPS6KA3 and cancer.